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F Ayad1, N Ayad1, YP Zhang2, W DeVizio2,
D Cummins2, and LR Mateo3
Comparing the Efficacy in Reducing Dentin Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Commercial Sensitive Toothpaste Containing 2% Potassium Ion: An Eight-Week Clinical Study on Canadian Adults
In: J Clin Dent 2009 (Spec Iss); 20: 10–16
1 Canadian Clinical Research Center, Mississauga, Ontario, Canada
2 Colgate-Palmolive Technology Center, Piscataway, NJ, USA
3 LRM Consulting, Hoboken, NJ, USA
The objective of the double-blind, randomized study conducted in Mississauga, Canada, was to compare a new toothpaste containing 8% arginine, calcium carbonate and 1450 ppm fluoride as sodium monofluorophosphate (MFP) and a commercial toothpaste containing 2% potassium ion and 1450 ppm fluoride as sodium fluoride (NaF) with respect to the reduction of dentine hypersensitivity over an eight-week period.
Trial conditions and methods
Products under investigation
Test: A new toothpaste (Colgate-Palmolive Inc., NY) containing 8% arginine, calcium carbonate and 1450 ppm fluoride as MFP. Control: Commercially available desensitising toothpaste containing 2% potassium ion as 3.75% potassium chloride and 1450 ppm fluoride as NaF in a silica
A total of 77 adult male (n = 25) and female (n = 52) subjects (age between 18 and 66 years) with established dentine hypersensitivity on at least two hypersensitive teeth with a tactile sensitivity score of 10 to 50 grams of force (Yeaple probe) and an air blast stimulus score of 2 or 3 (Schiff Cold Air Sensitivity Scale).
In this double-blind, parallel-group study, the 77 subjects with established dentine hypersensitivity were stratified according to their tactile and air blast stimulus scores at baseline and then randomly assigned within strata to either the test (n = 38) or control (n = 39) group. Subjects were instructed to brush their teeth twice a day (morning and evening) for 1 min each time. Tactile and air blast sensitivity assessments were repeated at 3 days and at 2, 4, and 8 weeks. Statistical analyses were done separately for tactile and air blast scores. Within-group comparisons were done using paired t-tests. Comparisons between treatments using baseline-adjusted scores were performed using analysis of covariance (ANCOVA).
When used over a period of 8 weeks, the novel toothpaste containing arginine and MFP in a calcium carbonate base significantly reduced dentine hypersensitivity (p < 0.05) in response to both the tactile and air blast stimuli. Compared to the commercial toothpaste with 2% potassium ion and NaF, the arginine containing toothpaste was significantly (p < 0.05) more effective in reducing hypersensitivity scores after 2, 4, and 8 weeks of use (16.2%, 22.4%, and 21.4% for tactile stimuli; 16.2%, 29.2%, and 63.4% for air blast stimuli).
A new toothpaste with 8% arginine, calcium carbonate and 1450 ppm fluoride (MFP) provided significantly (p < 0.05) greater dentine hypersensitivity relief after 2, 4, and 8 weeks of use than a desensitising toothpaste containing 2% potassium ion and 1450 ppm fluoride (NaF).