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The delivery of an active ingredient with antiplaque and anti-gingivitis benefits can be through a dentifrice or a mouth rinse. The incorporation of such an ingredient into a dentifrice is a particularly attractive option to augment mechanical cleaning procedures, as dentifrices are typically used along with a toothbrush for routine oral hygiene. A unique dentifrice, Colgate® Total® (Colgate-Palmolive Co., New York, NY, USA), has been developed and clinically proven to provide antiplaque and anti-gingivitis benefits when compared to a conventional fluoride dentifrice. This dentifrice contains a broad-spectrum anti-bacterial agent, triclosan, and a polyvinylmethyl ether/maleic acid (PVM/MA) copolymer to ensure uptake and retention of triclosan on the oral hard and soft tissues. Effective levels of triclosan are retained in the oral cavity 12 hours after brushing the teeth, allowing prolonged control of the oral bacteria that form plaque, and can cause gingivitis, calculus, and oral malodor.
The five research articles which appear in this special issue of the Journal of Clinical Dentistrypresent a series of laboratory and patient-based studies that compare the efficacy of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, and 0.243% sodium fluoride (Colgate® Total®) to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate (Crest Pro-Health®) for the control of established supragingival plaque and gingivitis. The studies reported in this Special Issue demonstrate evidence, using valid and robust in vitro, ex vivo, and in vivo methods, that a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, and 0.243% sodium fluoride (Colgate® Total®) provides superior plaque and gingivitis reduction versus a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate (Crest Pro-Health®). Based on these studies, as well as previous research, it is evident that Colgate Total will help provide patients with the best protection against plaque and gingivitis when used as part of a daily oral hygiene regimen.
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